{"id":27653,"date":"2023-02-26T15:06:24","date_gmt":"2023-02-26T14:06:24","guid":{"rendered":"https:\/\/transferencia.umh.es\/?p=27653"},"modified":"2026-10-05T12:28:38","modified_gmt":"2026-10-05T10:28:38","slug":"ensayo-farmacologico-en-modelos-experimentales-de-enfermedades-neuropsiquiatricas","status":"publish","type":"post","link":"https:\/\/transferencia.umh.es\/en\/2023\/02\/26\/ensayo-farmacologico-en-modelos-experimentales-de-enfermedades-neuropsiquiatricas\/","title":{"rendered":"Pharmacological Testing in Experimental Models of Neuropsychiatric Disorders"},"content":{"rendered":"<p><\/p>\n<article style=\"font-family: 'Arial', sans-serif;max-width: 800px;margin: 2rem auto;background-color: #fff;border: 1px solid #B6A19E;border-radius: 8px;padding: 2rem;line-height: 1.6;color: #000\"><!-- T\u00cdTULO Y SUBT\u00cdTULO --><\/p>\n<header style=\"border-left: 8px solid #A6192E;padding-left: 1rem;margin-bottom: 1.5rem\">\n<h1 class=\"px-2 my-10 text-lg font-extrabold tracking-normal lg:text-3xl md:mb-3 text-stone-700 dark:text-stone-300 fcircular\">Pharmacological Testing in Experimental Models of Neuropsychiatric Disorders<\/h1>\n<h2 style=\"margin: 0.3rem 0px 0px;font-size: 1.1rem;font-weight: 400;color: #444444;text-align: justify\">Studying the underlying biological mechanisms of neuropsychiatric disorders and their response to drugs is essential for the development of new therapies. The Translational Neuropsychopharmacology Group specialises in developing new cognitive-behavioural strategies and psychopharmacological treatments targeting these disorders. It therefore offers its collaboration in pre-competitive innovation and research projects aimed at developing new drugs to improve the clinical manifestations and progression of neuropsychiatric disorders<\/h2>\n<\/header>\n<section style=\"margin-bottom: 2rem\">\n<h3 style=\"background-color: #a6192e;color: #fff;padding: 0.5rem 1rem;border-radius: 4px 4px 0 0;font-size: 1.1rem\">TECHNOLOGY DESCRIPTION<\/h3>\n<div style=\"border-left: 4px solid #B6A19E;padding-left: 1rem;background-color: #f9f9f9;padding: 1rem\">\n<p>The testing and validation of therapeutic tools are essential for scientific and technical professionals (pharmacists, physicians, psychologists, biologists and biotechnologists) whose aim is to improve the quality of life of patients suffering from neuropsychiatric disorders. To this end, the Translational Neuropsychopharmacology Group offers the following technology:<\/p>\n<p><strong>Animal models for the assessment of motor activity<\/strong><\/p>\n<ul>\n<li>Open field test and behavioural assessment through video-based image analysis<\/li>\n<li>Neurological impairment assessment test<\/li>\n<\/ul>\n<p><strong>Assessment of stress response<\/strong><\/p>\n<ul>\n<li>Restraint stress<\/li>\n<li>Animal models of anxiety<\/li>\n<li>Light\u2013dark box<\/li>\n<li>Elevated plus maze<\/li>\n<li>Social interaction<\/li>\n<\/ul>\n<p><strong>Animal models of depression<\/strong><\/p>\n<ul>\n<li>Forced swim test<\/li>\n<li>Tail suspension test<\/li>\n<li>Novelty-suppressed feeding<\/li>\n<li>Chronic mild stress model<\/li>\n<\/ul>\n<p><strong>Animal models of psychosis<\/strong><\/p>\n<ul>\n<li>Prepulse inhibition<\/li>\n<\/ul>\n<p><strong>Animal models for cognitive assessment<\/strong><\/p>\n<ul>\n<li>Step-down test<\/li>\n<li>Object recognition<\/li>\n<\/ul>\n<p><strong>Animal models of dependence\/addiction<\/strong><\/p>\n<ul>\n<li>Conditioned place preference<\/li>\n<li>Voluntary ethanol consumption (two-bottle choice test)<\/li>\n<li>Ethanol binge-drinking models<\/li>\n<li>Ethanol self-administration<\/li>\n<li>Animal models of impulsivity<\/li>\n<li>Delayed reinforcement task<\/li>\n<li>Novelty seeking<\/li>\n<\/ul>\n<p><strong>Surgical techniques<\/strong><\/p>\n<ul>\n<li>Stereotaxic surgery in rats and mice<\/li>\n<li>Implantation of osmotic mini-pumps<\/li>\n<\/ul>\n<p><strong>Biochemical and Molecular Biology Techniques<\/strong><\/p>\n<ul>\n<li>Radioactive <i>in situ<\/i> hybridisation<\/li>\n<li>Binding and autoradiography techniques<\/li>\n<li>Immunohistochemistry techniques<\/li>\n<li>Western blot<\/li>\n<li>PCR genotyping<\/li>\n<li>Real-time polymerase chain reaction (RT-PCR)<\/li>\n<\/ul>\n<\/div>\n<\/section>\n<p><!-- APLICACIONES --><\/p>\n<section style=\"margin-bottom: 2rem\">\n<h3 style=\"background-color: #a6192e;color: #fff;padding: 0.5rem 1rem;border-radius: 4px 4px 0 0;font-size: 1.1rem\">TECHNOLOGY APPLICATIONS<\/h3>\n<div style=\"border-left: 4px solid #B6A19E;padding-left: 1rem;background-color: #f9f9f9;padding: 1rem\">\n<div class=\"w-full px-3 rounded-xl print:!w-full\">\n<div>\n<div class=\"w-full my-8\">\n<div class=\"w-full px-1 !max-w-full prose fcircular prose-stone prose-headings:text-green-innova prose-ul:leading-tight dark:prose-headings:text-stone-300 prose-li:marker:text-green-innova prose-p:text-justify prose-a:text-green-innova hover:prose-a:text-teal-500 prose-img:shadow-md prose-img:w-full prose-img:rounded-xl dark:prose-p:text-stone-400 dark:prose-li:text-stone-400\">\n<p>The Translational Neuropsychopharmacology Group offers a comprehensive platform for the multidisciplinary testing and validation of drugs targeting neuropsychiatric disorders, ranging from animal models of locomotor and behavioural activity to biochemical and molecular biology techniques.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<p><!-- VENTAJAS E INNOVACIONES --><\/p>\n<section style=\"margin-bottom: 2rem\">\n<h3 style=\"background-color: #a6192e;color: #fff;padding: 0.5rem 1rem;border-radius: 4px 4px 0 0;font-size: 1.1rem\">ADVANTAGES AND INNOVATIVE ASPECTS<\/h3>\n<div style=\"border-left: 4px solid #B6A19E;padding-left: 1rem;background-color: #f9f9f9;padding: 1rem\">\n<p>The group has state-of-the-art research facilities and equipment, as well as specialised scientific and technical staff.<\/p>\n<\/div>\n<\/section>\n<p><!-- GRADO DE DESARROLLO --><\/p>\n<section style=\"margin-bottom: 2rem\">\n<h3 style=\"background-color: #a6192e;color: #fff;padding: 0.5rem 1rem;border-radius: 4px 4px 0 0;font-size: 1.1rem\">DEVELOPMENT STAGE<\/h3>\n<div style=\"border-left: 4px solid #B6A19E;padding-left: 1rem;background-color: #f9f9f9;padding: 1rem\">\n<p>Fully operational. The group has the infrastructure, validated animal models and technical expertise required to initiate collaborative projects with companies and research organisations immediately.<\/p>\n<\/div>\n<\/section>\n<p><!-- SECTORES DE APLICACI\u00d3N --><\/p>\n<section style=\"margin-bottom: 2rem\">\n<h3 style=\"background-color: #a6192e;color: #fff;padding: 0.5rem 1rem;border-radius: 4px 4px 0 0;font-size: 1.1rem\">APPLICATION SECTORS<\/h3>\n<div style=\"border-left: 4px solid #B6A19E;padding-left: 1rem;background-color: #f9f9f9;padding: 1rem\">\n<ul>\n<li data-path-to-node=\"22,0,0\">Pharmaceutical and Biopharmaceutical Industry.<\/li>\n<li data-path-to-node=\"22,1,0\">Neuroscience Research Institutes.<\/li>\n<li data-path-to-node=\"22,2,0\">Preclinical Testing Companies (CROs).<\/li>\n<li data-path-to-node=\"22,3,0\">Nutraceutical and Functional Food Sector for Mental Wellbeing.<\/li>\n<\/ul>\n<\/div>\n<\/section>\n<p><!-- INVESTIGADOR PRINCIPAL --><\/p>\n<section style=\"margin-bottom: 2rem\">\n<h3 style=\"background-color: #a6192e;color: #fff;padding: 0.5rem 1rem;border-radius: 4px 4px 0 0;font-size: 1.1rem\">PRINCIPAL INVESTIGATOR<\/h3>\n<div style=\"border-left: 4px solid #B6A19E;padding-left: 1rem;background-color: #f9f9f9;padding: 1rem\">\n<p><strong>Jorge Manzanares Robles<\/strong> \u2013 Institute of Neurosciences<\/p>\n<\/div>\n<p><!-- CONTACTO --><\/p>\n<footer style=\"border-top: 2px solid #A6192E;padding-top: 1rem;margin-top: 2rem\"><strong>Contact details:<\/strong><\/p>\n<p style=\"margin: 0;font-weight: bold;color: #a6192e\">KNOWLEDGE TRANSFER SERVICE<\/p>\n<p style=\"margin: 0.3rem 0\"><strong><a style=\"color: #a6192e;text-decoration: none\"><span style=\"color: #000000\">email:<\/span> transferencia@umh.es<\/a><\/strong><br \/>\n<strong>Tel: +34 96 522 2599<\/strong><br \/>\n<strong><span style=\"color: #000000\">web: <\/span><a style=\"color: #a6192e;text-decoration: underline\" href=\"https:\/\/transferencia.umh.es\" target=\"_blank\" rel=\"noopener\">transferencia.umh.es<\/a><\/strong><\/p>\n<\/footer>\n<\/section>\n<\/article>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Pharmacological Testing in Experimental Models of Neuropsychiatric Disorders<br \/>\nStudying the underlying biological mechanisms of neuropsychiatric disorders and their response to drugs is essential for the development of new therapies. The Translational Neuropsychopharmacology Group specialises in developing new cognitive-behavioural strategies and psychopharmacological treatments targeting these disorders. It therefore offers its collaboration in pre-competitive innovation and research projects [&#8230;]<\/p>\n","protected":false},"author":1503,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_links_to":"","_links_to_target":""},"categories":[1518027,1517946],"tags":[1517987],"_links":{"self":[{"href":"https:\/\/transferencia.umh.es\/en\/wp-json\/wp\/v2\/posts\/27653"}],"collection":[{"href":"https:\/\/transferencia.umh.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/transferencia.umh.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/transferencia.umh.es\/en\/wp-json\/wp\/v2\/users\/1503"}],"replies":[{"embeddable":true,"href":"https:\/\/transferencia.umh.es\/en\/wp-json\/wp\/v2\/comments?post=27653"}],"version-history":[{"count":0,"href":"https:\/\/transferencia.umh.es\/en\/wp-json\/wp\/v2\/posts\/27653\/revisions"}],"wp:attachment":[{"href":"https:\/\/transferencia.umh.es\/en\/wp-json\/wp\/v2\/media?parent=27653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/transferencia.umh.es\/en\/wp-json\/wp\/v2\/categories?post=27653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/transferencia.umh.es\/en\/wp-json\/wp\/v2\/tags?post=27653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}